There is acknowledged variability across the biobanking industry from stated mission and goals for specimen collections to the tools and practices employed to acquire, store and annotate samples in inventory. Furthermore, strategies and methods for enabling sample procurement by the research community also vary from institution to institution. This study explores the fractured landscape of organizational goals, practices, and challenges and proposes solutions that seek to enable both advancement in biomedical research and the implementation of viable cost recovery approaches for biorepositories.